chemerin receptor (cml1_human)

FAMILY

Class A (Rhodopsin) Protein receptors Chemerin receptor chemerin receptor

GENE

CMKLR1 (CHEMR23, DEZ)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Chemerin-like receptor 1, Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
R
M
E
D
E
D
Y
N
T
10
                   
S
I
S
Y
G
D
E
Y
P
D
20
                   
Y
L
D
S
I
V
V
L
E
D
30
    TM1          
L
S
P
L
E
A
R
V
T
R
40
                   
I
F
L
V
V
V
Y
S
I
V
50
                   
C
F
L
G
I
L
G
N
G
L
60
                   
V
I
I
I
A
T
F
K
M
K
70
ICL1 TM2      
K
T
V
N
M
V
W
F
L
N
80
                   
L
A
V
A
D
F
L
F
N
V
90
                   
F
L
P
I
H
I
T
Y
A
A
100
    ECL1   TM3
M
D
Y
H
W
V
F
G
T
A
110
                   
M
C
K
I
S
N
F
L
L
I
120
                   
H
N
M
F
T
S
V
F
L
L
130
                   
T
I
I
S
S
D
R
C
I
S
140
      ICL2      
V
L
L
P
V
W
S
Q
N
H
150
  TM4            
R
S
V
R
L
A
Y
M
A
C
160
                   
M
V
I
W
V
L
A
F
F
L
170
                   
S
S
P
S
L
V
F
R
D
T
180
ECL2            
A
N
L
H
G
K
I
S
C
F
190
                   
N
N
F
S
L
S
T
P
G
S
200
        TM5      
S
S
W
P
T
H
S
Q
M
D
210
                   
P
V
G
Y
S
R
H
M
V
V
220
                   
T
V
T
R
F
L
C
G
F
L
230
                   
V
P
V
L
I
I
T
A
C
Y
240
                   
L
T
I
V
C
K
L
Q
R
N
250
  ICL3 TM6    
R
L
A
K
T
K
K
P
F
K
260
                   
I
I
V
T
I
I
I
T
F
F
270
                   
L
C
W
C
P
Y
H
T
L
N
280
            ECL3
L
L
E
L
H
H
T
A
M
P
290
TM7              
G
S
V
F
S
L
G
L
P
L
300
                   
A
T
A
L
A
I
A
N
S
C
310
                   
M
N
P
I
L
Y
V
F
M
G
320
H8                
Q
D
F
K
K
F
K
V
A
L
330
  C-term      
F
S
R
L
V
N
A
L
S
E
340
                   
D
T
G
H
S
S
Y
P
S
H
350
                   
R
S
F
T
K
M
S
S
M
N
360
                   
E
R
T
S
M
N
E
R
E
T
370
     
G
M
L

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 M K K ICL1ECL1 Y H W V F ECL1ICL2 P V W S Q N H R ICL2ECL2 D T A N L H G K I S C F N N F S L S T P G S S S W P ECL2ICL3 L A K T ICL3ECL3 T A M ECL3N-term M R M E D E D Y N T S I S Y G D E Y P D Y L D S I V V L E D L S N-termC-term S R L V N A L S E D T G H S S Y P S H R S F T K M S S M N E R T S M N E R E T G M L C-term P L E A R V T R I F L V V V Y S I V C F L G I L G N G L V I I I A T F K T V N M V W F L N L A V A D F L F N V F L P I H I T Y A A M D G T A M C K I S N F L L I H N M F T S V F L L T I I S S D R C I S V L L S V R L A Y M A C M V I W V L A F F L S S P S L V F R T H S Q M D P V G Y S R H M V V T V T R F L C G F L V P V L I I T A C Y L T I V C K L Q R N R K K P F K I I V T I I I T F F L C W C P Y H T L N L L E L H H P G S V F S L G L P L A T A L A I A N S C M N P I L Y V F M G Q D K V A F K K F L F
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G L I G L F C V I S Y V V V L F I R 1 L N L A V A D F L F N V F L P I H I T Y 2 I T L L F V S T F M N H I L L F N S I K 3 A Y M A C M V I W V L A F F L S S P S 4 Y C A T I I L V P V L F G C L F R T V T V 5 V T I I I T F F L C W C P Y H T L N L L 6 I P N M C S N A I A L A T A L P L G L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

EPA, resolvin E1, chemerin, chemerin C-terminal peptide, 18R-HEPE

STRUCTURE MODELS

cml1_human inactive,

cml1_human active

STRUCTURES

Found 2 structure(s) - view all details on the Structures page

PDBs: 7YKD, 8SG1